Drug interactions
Cefazolin + Cholera vaccine
Severity: Moderate
Cefazolin and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine can be inactivated by active antibiotics, reducing immune response. A single perioperative cefazolin dose is less likely to matter but the labeling advice still applies.
What this interaction means in plain words
Cefazolin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
What to do
Avoid vaccination within 14 days of systemic antibiotic use, as per labeling; defer the vaccine until the course is completed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefazolin
- Amikacin + Cefazolin Moderate
- Bcg vaccine live + Cefazolin Moderate
- Cefazolin + Dexamethasone-tobramycin Moderate
- Cefazolin + Gentamicin Moderate
- Cefazolin + Kanamycin Moderate
- Cefazolin + Microbiota Moderate
Frequently asked questions
Can I take Cefazolin with Cholera vaccine?
MediHelp rates the interaction as moderate. Cefazolin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine can be inactivated by active antibiotics, reducing immune response. A single perioperative cefazolin dose is less likely to matter but the labeling advice still applies.
How serious is the interaction between Cefazolin and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days of systemic antibiotic use, as per labeling; defer the vaccine until the course is completed.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Dexamethasone-tobramycin. The full list is on the Cefazolin page.
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