Drug interactions
Cefepime + Cholera vaccine
Severity: Moderate
Cefepime and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral cholera vaccine is a live attenuated bacterial strain that must replicate in the gut to induce immunity. Systemic antibiotics reaching the gut may reduce the strain's viability and weaken the immune response.
What this interaction means in plain words
Cefepime and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The antibacterial activity can reduce replication of the live attenuated vaccine strain.
What to do
Do not give the vaccine to patients who received oral or parenteral antibiotics in the preceding 14 days; delay vaccination until after this interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefepime
- Amikacin + Cefepime Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Cefepime with Cholera vaccine?
MediHelp rates the interaction as moderate. Cefepime and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral cholera vaccine is a live attenuated bacterial strain that must replicate in the gut to induce immunity. Systemic antibiotics reaching the gut may reduce the strain's viability and weaken the immune response.
How serious is the interaction between Cefepime and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who received oral or parenteral antibiotics in the preceding 14 days; delay vaccination until after this interval.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Dexamethasone-tobramycin, Gentamicin. The full list is on the Cefepime page.
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