Drug interactions
Cefepime / enmetazobactam + Streptomycin
Severity: Moderate
Cefepime / enmetazobactam and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptomycin is nephrotoxic and ototoxic, and combining it with another beta-lactam agent could add to kidney stress. Cefepime has a low nephrotoxic potential alone, but impaired renal function can raise streptomycin exposure and the risk of ototoxicity.
What this interaction means in plain words
Cefepime / enmetazobactam and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity, with reduced renal clearance of streptomycin if kidney function declines.
What to do
Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Cefepime / enmetazobactam with Streptomycin?
MediHelp rates the interaction as moderate. Cefepime / enmetazobactam and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, and combining it with another beta-lactam agent could add to kidney stress. Cefepime has a low nephrotoxic potential alone, but impaired renal function can raise streptomycin exposure and the risk of ototoxicity.
How serious is the interaction between Cefepime / enmetazobactam and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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