Drug interactions
Cefepime / enmetazobactam + Tobramycin
Severity: Moderate
Cefepime / enmetazobactam and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins given with aminoglycosides have been associated with a higher rate of kidney injury in some reports. Cefepime is not itself strongly nephrotoxic, but the combination is common in severely ill patients. Clinically significant harm is uncommon but possible.
What this interaction means in plain words
Cefepime / enmetazobactam and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive renal tubular injury; the mechanism is not firmly established.
What to do
Monitor serum creatinine and urine output during combined therapy. Use tobramycin level-guided dosing and keep the course as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Tobramycin?
MediHelp rates the interaction as moderate. Cefepime / enmetazobactam and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins given with aminoglycosides have been associated with a higher rate of kidney injury in some reports. Cefepime is not itself strongly nephrotoxic, but the combination is common in severely ill patients. Clinically significant harm is uncommon but possible.
How serious is the interaction between Cefepime / enmetazobactam and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy. Use tobramycin level-guided dosing and keep the course as short as possible.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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