Drug interactions
Cefotaxime + Microbiota
Severity: Moderate
Cefotaxime and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral fecal microbiota products contain live bacterial spores intended to recolonize the gut. A systemic cephalosporin that is still present may reduce the viability or engraftment of these organisms and weaken the preventive effect against recurrent C. difficile infection.
What this interaction means in plain words
Cefotaxime and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live bacterial components of the product reduces colonization (pharmacodynamic antagonism).
What to do
Finish the antibiotic course and allow a washout interval of a few days before starting the microbiota product, as the labeling advises. Do not give the product during active cephalosporin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefotaxime
- Cefotaxime + Typhoid vaccine live Major
- Amikacin + Cefotaxime Moderate
- Cefotaxime + Cholera vaccine Moderate
- Cefotaxime + Dexamethasone-tobramycin Moderate
- Cefotaxime + Gentamicin Moderate
- Cefotaxime + Kanamycin Moderate
Frequently asked questions
Can I take Cefotaxime with Microbiota?
MediHelp rates the interaction as moderate. Cefotaxime and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral fecal microbiota products contain live bacterial spores intended to recolonize the gut. A systemic cephalosporin that is still present may reduce the viability or engraftment of these organisms and weaken the preventive effect against recurrent C. difficile infection.
How serious is the interaction between Cefotaxime and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Finish the antibiotic course and allow a washout interval of a few days before starting the microbiota product, as the labeling advises. Do not give the product during active cephalosporin therapy.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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