Drug interactions
Cefoxitin + Dexamethasone-tobramycin
Severity: Moderate
Cefoxitin and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefoxitin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with renal impairment or volume depletion.
What this interaction means in plain words
Cefoxitin and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; mechanism not firmly established.
What to do
Monitor serum creatinine and tobramycin concentrations, and adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefoxitin and Dexamethasone-tobramycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Gentamicin Moderate
Frequently asked questions
Can I take Cefoxitin with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Cefoxitin and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefoxitin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with renal impairment or volume depletion.
How serious is the interaction between Cefoxitin and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin concentrations, and adjust doses for renal function.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
