Drug interactions
Amikacin + Cefoxitin
Severity: Moderate
Amikacin and Cefoxitin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amikacin is nephrotoxic and ototoxic, and concurrent cephalosporins have been linked in some reports with additional kidney injury. Reduced renal function increases aminoglycoside accumulation and the risk of hearing damage.
What this interaction means in plain words
Amikacin and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefoxitin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with decreased renal clearance raising aminoglycoside exposure.
What to do
Monitor serum creatinine and amikacin levels, and ask about hearing or balance symptoms. Adjust the amikacin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefoxitin
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
- Cefoxitin + Gentamicin Moderate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Cefoxitin?
MediHelp rates the interaction as moderate. Amikacin and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and concurrent cephalosporins have been linked in some reports with additional kidney injury. Reduced renal function increases aminoglycoside accumulation and the risk of hearing damage.
How serious is the interaction between Amikacin and Cefoxitin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and ask about hearing or balance symptoms. Adjust the amikacin dose to renal function.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Aztreonam, Bcg vaccine live, Chloramphenicol. The full list is on the Cefoxitin page.
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