Drug interactions
Ceftobiprole medocaril + Glyburide-metformin
Severity: Moderate
Ceftobiprole medocaril and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro and may raise glyburide levels, since glyburide is an OATP substrate. Higher glyburide exposure increases the risk of hypoglycemia.
What this interaction means in plain words
Ceftobiprole medocaril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake reduces glyburide hepatic clearance.
What to do
Monitor blood glucose closely during ceftobiprole therapy and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Ceftobiprole medocaril with Glyburide-metformin?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro and may raise glyburide levels, since glyburide is an OATP substrate. Higher glyburide exposure increases the risk of hypoglycemia.
How serious is the interaction between Ceftobiprole medocaril and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during ceftobiprole therapy and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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