Drug interactions
Ceftobiprole medocaril + Irinotecan
Severity: Moderate
Ceftobiprole medocaril and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3, which transport SN-38 into hepatocytes for glucuronidation. Higher SN-38 levels could heighten diarrhea and myelosuppression, though clinical data are lacking.
What this interaction means in plain words
Ceftobiprole medocaril and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake may reduce SN-38 hepatic clearance.
What to do
Monitor for diarrhea and neutropenia if combined and consider an alternative antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Ceftobiprole medocaril with Irinotecan?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3, which transport SN-38 into hepatocytes for glucuronidation. Higher SN-38 levels could heighten diarrhea and myelosuppression, though clinical data are lacking.
How serious is the interaction between Ceftobiprole medocaril and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia if combined and consider an alternative antibiotic when feasible.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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