Drug interactions
Ceftobiprole medocaril + Metformin-repaglinide
Severity: Moderate
Ceftobiprole medocaril and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3, which mediate hepatic uptake of repaglinide. Higher repaglinide exposure may cause hypoglycemia.
What this interaction means in plain words
Ceftobiprole medocaril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of repaglinide.
What to do
Monitor blood glucose during ceftobiprole therapy and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Ceftobiprole medocaril with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3, which mediate hepatic uptake of repaglinide. Higher repaglinide exposure may cause hypoglycemia.
How serious is the interaction between Ceftobiprole medocaril and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during ceftobiprole therapy and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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