Drug interactions
Ceftobiprole medocaril + Valsartan
Severity: Minor
Ceftobiprole medocaril and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3, and valsartan is a substrate of OATP1B1, so valsartan exposure may rise. The effect is likely modest and short-lived with a brief antibiotic course.
What this interaction means in plain words
Ceftobiprole medocaril and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake reduces valsartan hepatic clearance.
What to do
No dose change needed; monitor blood pressure for hypotension during ceftobiprole therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Ceftobiprole medocaril with Valsartan?
MediHelp rates the interaction as minor. Ceftobiprole medocaril and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits OATP1B1 and OATP1B3, and valsartan is a substrate of OATP1B1, so valsartan exposure may rise. The effect is likely modest and short-lived with a brief antibiotic course.
How serious is the interaction between Ceftobiprole medocaril and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor blood pressure for hypotension during ceftobiprole therapy.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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