Drug interactions
Ceftriaxone + Dienogest / estradiol valerate
Severity: Minor
Ceftriaxone and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to reduce the effectiveness of oral hormonal contraceptives by altering gut flora. Controlled data show no consistent fall in hormone levels for non-enzyme-inducing antibiotics, so any risk is small.
What this interaction means in plain words
Ceftriaxone and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogen through altered intestinal flora.
What to do
No routine change is needed. Remind the patient to follow missed-dose rules if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Frequently asked questions
Can I take Ceftriaxone with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Ceftriaxone and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to reduce the effectiveness of oral hormonal contraceptives by altering gut flora. Controlled data show no consistent fall in hormone levels for non-enzyme-inducing antibiotics, so any risk is small.
How serious is the interaction between Ceftriaxone and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Remind the patient to follow missed-dose rules if vomiting or diarrhea occurs.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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