Drug interactions
Ceftriaxone + Kanamycin
Severity: Moderate
Ceftriaxone and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a cephalosporin with an aminoglycoside may add to kidney injury, and kanamycin can also damage hearing and balance. Risk is higher with renal impairment, advanced age or prolonged therapy.
What this interaction means in plain words
Ceftriaxone and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic potential, with aminoglycoside-related tubular injury and ototoxicity.
What to do
Monitor serum creatinine and urine output and adjust kanamycin dosing to renal function, using drug levels where available. Ask about tinnitus, hearing loss or vertigo.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Frequently asked questions
Can I take Ceftriaxone with Kanamycin?
MediHelp rates the interaction as moderate. Ceftriaxone and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may add to kidney injury, and kanamycin can also damage hearing and balance. Risk is higher with renal impairment, advanced age or prolonged therapy.
How serious is the interaction between Ceftriaxone and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output and adjust kanamycin dosing to renal function, using drug levels where available. Ask about tinnitus, hearing loss or vertigo.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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