Drug interactions
Ceftriaxone + Neomycin po
Severity: Minor
Ceftriaxone and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in healthy gut, so systemic exposure is usually small. Absorption can rise with damaged bowel mucosa or renal impairment, and in that case any additive nephrotoxicity with a cephalosporin becomes relevant.
What this interaction means in plain words
Ceftriaxone and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive nephrotoxicity if neomycin is absorbed systemically.
What to do
No routine action is needed with intact bowel and normal renal function. In renal impairment or inflamed bowel, monitor serum creatinine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Frequently asked questions
Can I take Ceftriaxone with Neomycin po?
MediHelp rates the interaction as minor. Ceftriaxone and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed in healthy gut, so systemic exposure is usually small. Absorption can rise with damaged bowel mucosa or renal impairment, and in that case any additive nephrotoxicity with a cephalosporin becomes relevant.
How serious is the interaction between Ceftriaxone and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with intact bowel and normal renal function. In renal impairment or inflamed bowel, monitor serum creatinine.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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