Drug interactions
Cefuroxime + Demeclocycline
Severity: Moderate
Cefuroxime and Demeclocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may theoretically blunt the killing action of beta-lactams, which depend on actively dividing bacteria. Clinical significance is uncertain, but it may matter in serious infections such as meningitis or endocarditis.
What this interaction means in plain words
Cefuroxime and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis reduces the growth-dependent bactericidal activity of cefuroxime.
What to do
Avoid combining in severe infections where bactericidal activity is essential; otherwise monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Cefuroxime with Demeclocycline?
MediHelp rates the interaction as moderate. Cefuroxime and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may theoretically blunt the killing action of beta-lactams, which depend on actively dividing bacteria. Clinical significance is uncertain, but it may matter in serious infections such as meningitis or endocarditis.
How serious is the interaction between Cefuroxime and Demeclocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in severe infections where bactericidal activity is essential; otherwise monitor clinical response.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
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