Drug interactions
Cefuroxime + Dexamethasone-tobramycin
Severity: Minor
Cefuroxime and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefuroxime given with an aminoglycoside may modestly raise the risk of kidney injury, mainly in patients with other risk factors. Aminoglycoside nephrotoxicity and ototoxicity are the main concern.
What this interaction means in plain words
Cefuroxime and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefuroxime belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; the mechanism is not firmly established.
What to do
Monitor serum creatinine and hydration status, and adjust tobramycin dosing according to renal function and drug levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Cefuroxime with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Cefuroxime and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefuroxime given with an aminoglycoside may modestly raise the risk of kidney injury, mainly in patients with other risk factors. Aminoglycoside nephrotoxicity and ototoxicity are the main concern.
How serious is the interaction between Cefuroxime and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and hydration status, and adjust tobramycin dosing according to renal function and drug levels.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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