Drug interactions
Cefuroxime + Dienogest / estradiol valerate
Severity: Minor
Cefuroxime and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorised to reduce hormone levels through effects on gut flora. Studies with non-rifamycin antibiotics have generally not shown clinically meaningful drops in contraceptive hormones, so failure is unlikely.
What this interaction means in plain words
Cefuroxime and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical decrease in enterohepatic recirculation of estrogen due to altered gut flora.
What to do
No routine additional contraception is needed; advise backup contraception if vomiting or severe diarrhoea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Cefuroxime with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Cefuroxime and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorised to reduce hormone levels through effects on gut flora. Studies with non-rifamycin antibiotics have generally not shown clinically meaningful drops in contraceptive hormones, so failure is unlikely.
How serious is the interaction between Cefuroxime and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine additional contraception is needed; advise backup contraception if vomiting or severe diarrhoea occurs.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
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