Drug interactions
Cefuroxime + Rabeprazole
Severity: Moderate
Cefuroxime and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Absorption of cefuroxime axetil is reduced when gastric acidity is suppressed, which may lower antibiotic exposure. Treatment failure is possible in more serious infections.
What this interaction means in plain words
Cefuroxime and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefuroxime belongs to Anti Bacterial; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces dissolution and absorption of cefuroxime axetil.
What to do
Give cefuroxime axetil with food to improve absorption, or use a different antibiotic if acid suppression must continue and infection is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Cefuroxime with Rabeprazole?
MediHelp rates the interaction as moderate. Cefuroxime and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Absorption of cefuroxime axetil is reduced when gastric acidity is suppressed, which may lower antibiotic exposure. Treatment failure is possible in more serious infections.
How serious is the interaction between Cefuroxime and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefuroxime axetil with food to improve absorption, or use a different antibiotic if acid suppression must continue and infection is significant.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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