Drug interactions
Celiprolol + Dobutamine
Severity: Moderate
Celiprolol and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol is a beta-blocker with beta-1 antagonism and weak beta-2 partial agonism, so it can blunt the inotropic and chronotropic response to dobutamine. Reduced cardiac output response may occur in patients who need inotropic support.
What this interaction means in plain words
Celiprolol and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-1 adrenergic receptors.
What to do
Monitor hemodynamic response and titrate the dobutamine dose to effect, which may need to be higher. Consider whether the beta-blocker should be held in patients requiring inotropic support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celiprolol and Dobutamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dobutamine
Frequently asked questions
Can I take Celiprolol with Dobutamine?
MediHelp rates the interaction as moderate. Celiprolol and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol is a beta-blocker with beta-1 antagonism and weak beta-2 partial agonism, so it can blunt the inotropic and chronotropic response to dobutamine. Reduced cardiac output response may occur in patients who need inotropic support.
How serious is the interaction between Celiprolol and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemodynamic response and titrate the dobutamine dose to effect, which may need to be higher. Consider whether the beta-blocker should be held in patients requiring inotropic support.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
