Drug interactions
Celiprolol + Fluticasone-salmeterol
Severity: Moderate
Celiprolol and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol is a beta-blocker with beta-1 selectivity and partial beta-2 agonist activity. It can blunt the bronchodilator effect of salmeterol and in susceptible patients may provoke bronchospasm. The effect is less likely than with nonselective agents but matters in asthma or COPD.
What this interaction means in plain words
Celiprolol and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of beta-2 receptor agonism by the beta-blocker.
What to do
Monitor respiratory symptoms and peak flow or lung function. Consider an alternative non-beta-blocker antihypertensive in patients with significant reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Celiprolol with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Celiprolol and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol is a beta-blocker with beta-1 selectivity and partial beta-2 agonist activity. It can blunt the bronchodilator effect of salmeterol and in susceptible patients may provoke bronchospasm. The effect is less likely than with nonselective agents but matters in asthma or COPD.
How serious is the interaction between Celiprolol and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and peak flow or lung function. Consider an alternative non-beta-blocker antihypertensive in patients with significant reactive airway disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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