Drug interactions
Celiprolol + Ibuprofen
Severity: Moderate
Celiprolol and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ibuprofen can reduce the blood pressure lowering effect of beta-blockers, especially with sustained use. Renal effects of NSAIDs may also contribute to fluid retention and mildly raised potassium.
What this interaction means in plain words
Celiprolol and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ibuprofen inhibits vasodilatory prostaglandin synthesis and promotes sodium and water retention, opposing the antihypertensive action of the beta-blocker.
What to do
Monitor blood pressure when ibuprofen is used regularly for more than a few days, and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Celiprolol with Ibuprofen?
MediHelp rates the interaction as moderate. Celiprolol and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ibuprofen can reduce the blood pressure lowering effect of beta-blockers, especially with sustained use. Renal effects of NSAIDs may also contribute to fluid retention and mildly raised potassium.
How serious is the interaction between Celiprolol and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ibuprofen is used regularly for more than a few days, and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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