Drug interactions
Celiprolol + Meclofenamic acid
Severity: Moderate
Celiprolol and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the blood pressure lowering effect of beta-blockers, particularly with continued use. Blood pressure control may worsen.
What this interaction means in plain words
Celiprolol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and vasoconstriction, opposing the antihypertensive effect.
What to do
Monitor blood pressure when starting or stopping the NSAID and adjust antihypertensive dosing as needed. Limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Celiprolol with Meclofenamic acid?
MediHelp rates the interaction as moderate. Celiprolol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt the blood pressure lowering effect of beta-blockers, particularly with continued use. Blood pressure control may worsen.
How serious is the interaction between Celiprolol and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID and adjust antihypertensive dosing as needed. Limit NSAID dose and duration.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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