Drug interactions
Celiprolol + Spironolactone
Severity: Minor
Celiprolol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can modestly raise serum potassium by impairing cellular potassium uptake, which adds to the hyperkalemic effect of spironolactone. The risk is greater in renal impairment, diabetes and older patients.
What this interaction means in plain words
Celiprolol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-blockade reduces beta-2-mediated cellular potassium uptake, adding to spironolactone's reduced renal potassium excretion.
What to do
Monitor serum potassium and renal function, especially at initiation and in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Celiprolol with Spironolactone?
MediHelp rates the interaction as minor. Celiprolol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers can modestly raise serum potassium by impairing cellular potassium uptake, which adds to the hyperkalemic effect of spironolactone. The risk is greater in renal impairment, diabetes and older patients.
How serious is the interaction between Celiprolol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially at initiation and in patients with renal impairment.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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