Drug interactions
Cenobamate + Clonazepam
Severity: Moderate
Cenobamate and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower clonazepam concentrations, potentially reducing seizure control. Both drugs also cause somnolence and dizziness, so additive sedation is possible.
What this interaction means in plain words
Cenobamate and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4, increasing clonazepam clearance, with additive CNS depressant effects.
What to do
Monitor seizure control and sedation, and adjust the clonazepam dose according to clinical response. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Clonazepam?
MediHelp rates the interaction as moderate. Cenobamate and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower clonazepam concentrations, potentially reducing seizure control. Both drugs also cause somnolence and dizziness, so additive sedation is possible.
How serious is the interaction between Cenobamate and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and adjust the clonazepam dose according to clinical response. Reassess the dose if cenobamate is stopped.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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