Drug interactions
Cenobamate + Clozapine
Severity: Moderate
Cenobamate and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence and dizziness, so combined use can increase sedation and impair coordination. Cenobamate also induces CYP3A4 and may lower clozapine levels, and clozapine lowers the seizure threshold.
What this interaction means in plain words
Cenobamate and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP3A4 induction by cenobamate reducing clozapine exposure.
What to do
Monitor sedation, seizure control and psychiatric response, and check clozapine levels if control worsens. Titrate cenobamate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Clozapine?
MediHelp rates the interaction as moderate. Cenobamate and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause somnolence and dizziness, so combined use can increase sedation and impair coordination. Cenobamate also induces CYP3A4 and may lower clozapine levels, and clozapine lowers the seizure threshold.
How serious is the interaction between Cenobamate and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, seizure control and psychiatric response, and check clozapine levels if control worsens. Titrate cenobamate slowly.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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