Drug interactions
Cenobamate + Codeine
Severity: Moderate
Cenobamate and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate often causes somnolence and dizziness, and codeine adds opioid sedation and respiratory depression. Cenobamate also modulates CYP enzymes, which may alter opioid exposure.
What this interaction means in plain words
Cenobamate and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression; cenobamate may also affect CYP2B6 and CYP3A4 activity.
What to do
Monitor sedation and respiratory function and review analgesic response. Reduce doses if somnolence is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Codeine?
MediHelp rates the interaction as moderate. Cenobamate and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate often causes somnolence and dizziness, and codeine adds opioid sedation and respiratory depression. Cenobamate also modulates CYP enzymes, which may alter opioid exposure.
How serious is the interaction between Cenobamate and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function and review analgesic response. Reduce doses if somnolence is excessive.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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