Drug interactions
Cenobamate + Cyclophosphamide
Severity: Moderate
Cenobamate and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP2B6 and CYP3A4. Induction may speed conversion of cyclophosphamide to its active and toxic metabolites. This could shift the balance between efficacy and toxicity such as myelosuppression or hemorrhagic cystitis.
What this interaction means in plain words
Cenobamate and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Cyclophosphamide belongs to Oncology.
Why it happens
Induction of CYP2B6 and CYP3A4 by cenobamate alters cyclophosphamide bioactivation.
What to do
Monitor blood counts, urinary symptoms and response when starting or stopping cenobamate. Consider an alternative antiseizure drug without enzyme induction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Cyclophosphamide?
MediHelp rates the interaction as moderate. Cenobamate and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP2B6 and CYP3A4. Induction may speed conversion of cyclophosphamide to its active and toxic metabolites. This could shift the balance between efficacy and toxicity such as myelosuppression or hemorrhagic cystitis.
How serious is the interaction between Cenobamate and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, urinary symptoms and response when starting or stopping cenobamate. Consider an alternative antiseizure drug without enzyme induction.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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