Drug interactions
Cenobamate + Cyclosporin
Severity: Moderate
Cenobamate and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower cyclosporine concentrations. Subtherapeutic levels could lead to transplant rejection or loss of disease control.
What this interaction means in plain words
Cenobamate and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Cenobamate induction of CYP3A4 increases cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels after starting, changing or stopping cenobamate and increase the cyclosporine dose as needed. Readjust the dose if cenobamate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Cyclosporin?
MediHelp rates the interaction as moderate. Cenobamate and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower cyclosporine concentrations. Subtherapeutic levels could lead to transplant rejection or loss of disease control.
How serious is the interaction between Cenobamate and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting, changing or stopping cenobamate and increase the cyclosporine dose as needed. Readjust the dose if cenobamate is withdrawn.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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