Drug interactions
Cenobamate + Diphenoxylate-atropine
Severity: Moderate
Cenobamate and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and impaired coordination. Combined with the opioid diphenoxylate, sedation and impairment may be increased.
What this interaction means in plain words
Cenobamate and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Monitor for excess sedation and dizziness, and advise caution with driving. Use the lowest effective diphenoxylate-atropine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Cenobamate and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and impaired coordination. Combined with the opioid diphenoxylate, sedation and impairment may be increased.
How serious is the interaction between Cenobamate and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, and advise caution with driving. Use the lowest effective diphenoxylate-atropine dose.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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