Drug interactions
Cenobamate + Erlotinib
Severity: Moderate
Cenobamate and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce erlotinib concentrations. This risks reduced efficacy of erlotinib.
What this interaction means in plain words
Cenobamate and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Erlotinib belongs to Oncology.
Why it happens
Cenobamate induces CYP3A4, accelerating erlotinib metabolism.
What to do
Monitor tumor response and consider an erlotinib dose increase in 50 mg steps as tolerated. Reduce the dose again if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Erlotinib?
MediHelp rates the interaction as moderate. Cenobamate and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce erlotinib concentrations. This risks reduced efficacy of erlotinib.
How serious is the interaction between Cenobamate and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider an erlotinib dose increase in 50 mg steps as tolerated. Reduce the dose again if cenobamate is stopped.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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