Drug interactions
Cenobamate + Fluticasone-salmeterol
Severity: Minor
Cenobamate and Fluticasone-salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4, which could lower systemic exposure to inhaled fluticasone and salmeterol. The clinical relevance is likely modest because inhaled doses act locally, but loss of asthma or COPD control is possible.
What this interaction means in plain words
Cenobamate and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Induction of CYP3A4 by cenobamate increases the metabolism of salmeterol and fluticasone.
What to do
Monitor respiratory control and symptoms after cenobamate is started or titrated. Adjust the inhaled regimen only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Fluticasone-salmeterol?
MediHelp rates the interaction as minor. Cenobamate and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate induces CYP3A4, which could lower systemic exposure to inhaled fluticasone and salmeterol. The clinical relevance is likely modest because inhaled doses act locally, but loss of asthma or COPD control is possible.
How serious is the interaction between Cenobamate and Fluticasone-salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory control and symptoms after cenobamate is started or titrated. Adjust the inhaled regimen only if control worsens.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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