Drug interactions
Cenobamate + Ifosfamide
Severity: Moderate
Cenobamate and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and inhibits CYP2C19, both of which are involved in ifosfamide metabolism. The net effect on active and neurotoxic metabolites is unpredictable.
What this interaction means in plain words
Cenobamate and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Ifosfamide belongs to Oncology.
Why it happens
Cenobamate induces CYP3A4 and inhibits CYP2C19, altering ifosfamide metabolism.
What to do
Monitor for ifosfamide efficacy and toxicity, particularly encephalopathy and myelosuppression. Avoid empirical dose changes and adjust based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Ifosfamide?
MediHelp rates the interaction as moderate. Cenobamate and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and inhibits CYP2C19, both of which are involved in ifosfamide metabolism. The net effect on active and neurotoxic metabolites is unpredictable.
How serious is the interaction between Cenobamate and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ifosfamide efficacy and toxicity, particularly encephalopathy and myelosuppression. Avoid empirical dose changes and adjust based on clinical response.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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