Drug interactions
Cenobamate + Imipramine
Severity: Moderate
Cenobamate and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19 and may increase imipramine exposure, though it induces other enzymes so the net effect varies. Raised tricyclic levels could cause anticholinergic effects, sedation and arrhythmia risk.
What this interaction means in plain words
Cenobamate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated imipramine metabolism by cenobamate.
What to do
Monitor clinical response and tricyclic adverse effects; consider imipramine dose reduction or plasma level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Imipramine?
MediHelp rates the interaction as moderate. Cenobamate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate inhibits CYP2C19 and may increase imipramine exposure, though it induces other enzymes so the net effect varies. Raised tricyclic levels could cause anticholinergic effects, sedation and arrhythmia risk.
How serious is the interaction between Cenobamate and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tricyclic adverse effects; consider imipramine dose reduction or plasma level monitoring.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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