Drug interactions
Cenobamate + Lorazepam
Severity: Moderate
Cenobamate and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, which can be amplified by lorazepam. Cognitive and motor impairment may be more pronounced.
What this interaction means in plain words
Cenobamate and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A modulation and sodium channel inhibition.
What to do
Monitor for sedation and impaired coordination, titrate cenobamate slowly, and reduce the benzodiazepine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Lorazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lorazepam
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Lorazepam?
MediHelp rates the interaction as moderate. Cenobamate and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, which can be amplified by lorazepam. Cognitive and motor impairment may be more pronounced.
How serious is the interaction between Cenobamate and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and impaired coordination, titrate cenobamate slowly, and reduce the benzodiazepine dose if needed.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
