Drug interactions
Cenobamate + Nifedipine
Severity: Moderate
Cenobamate and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower nifedipine concentrations. This may reduce blood pressure or angina control.
What this interaction means in plain words
Cenobamate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by cenobamate increases nifedipine metabolism and reduces its exposure.
What to do
Monitor blood pressure and anginal symptoms when cenobamate is started or stopped. Increase the nifedipine dose as needed, and reduce it if cenobamate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nifedipine
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Nifedipine?
MediHelp rates the interaction as moderate. Cenobamate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower nifedipine concentrations. This may reduce blood pressure or angina control.
How serious is the interaction between Cenobamate and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms when cenobamate is started or stopped. Increase the nifedipine dose as needed, and reduce it if cenobamate is withdrawn.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
