Drug interactions
Cenobamate + Quinine
Severity: Moderate
Cenobamate and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower quinine plasma concentrations. This may reduce antimalarial efficacy and risk treatment failure.
What this interaction means in plain words
Cenobamate and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by cenobamate, increasing quinine metabolism.
What to do
Monitor for reduced response to quinine and consider an alternative antimalarial or a higher dose if clinically appropriate. Review the need for dose adjustment when cenobamate is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Quinine?
MediHelp rates the interaction as moderate. Cenobamate and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower quinine plasma concentrations. This may reduce antimalarial efficacy and risk treatment failure.
How serious is the interaction between Cenobamate and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to quinine and consider an alternative antimalarial or a higher dose if clinically appropriate. Review the need for dose adjustment when cenobamate is started or stopped.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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