Drug interactions
Cenobamate + Repaglinide
Severity: Moderate
Cenobamate and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower repaglinide concentrations, reducing its glucose-lowering effect. Glycemic control may worsen.
What this interaction means in plain words
Cenobamate and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Induction of CYP3A4 increases repaglinide metabolism.
What to do
Monitor blood glucose after starting cenobamate and increase the repaglinide dose if needed. Re-evaluate the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Repaglinide?
MediHelp rates the interaction as moderate. Cenobamate and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower repaglinide concentrations, reducing its glucose-lowering effect. Glycemic control may worsen.
How serious is the interaction between Cenobamate and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting cenobamate and increase the repaglinide dose if needed. Re-evaluate the dose if cenobamate is stopped.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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