Drug interactions
Cenobamate + Sunitinib
Severity: Moderate
Cenobamate and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower sunitinib and its active metabolite concentrations, reducing antitumor efficacy.
What this interaction means in plain words
Cenobamate and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
CYP3A4 induction by cenobamate increases sunitinib clearance.
What to do
Consider an alternative antiseizure drug without enzyme induction. If unavoidable, monitor response and consider increasing the sunitinib dose stepwise as tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Sunitinib?
MediHelp rates the interaction as moderate. Cenobamate and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower sunitinib and its active metabolite concentrations, reducing antitumor efficacy.
How serious is the interaction between Cenobamate and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiseizure drug without enzyme induction. If unavoidable, monitor response and consider increasing the sunitinib dose stepwise as tolerated.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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