Drug interactions
Cenobamate + Tadalafil
Severity: Moderate
Cenobamate and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and can lower tadalafil exposure. This may reduce the effectiveness of tadalafil for erectile dysfunction or pulmonary arterial hypertension.
What this interaction means in plain words
Cenobamate and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Cenobamate induces CYP3A4, increasing the metabolism of tadalafil.
What to do
Monitor for reduced tadalafil response and increase the dose within labeled limits if needed. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Tadalafil?
MediHelp rates the interaction as moderate. Cenobamate and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and can lower tadalafil exposure. This may reduce the effectiveness of tadalafil for erectile dysfunction or pulmonary arterial hypertension.
How serious is the interaction between Cenobamate and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tadalafil response and increase the dose within labeled limits if needed. Reassess the dose if cenobamate is stopped.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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