Drug interactions
Cephalexin + Empagliflozin-metformin
Severity: Moderate
Cephalexin and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin may reduce renal tubular secretion of metformin and increase its plasma concentrations. This raises the risk of metformin accumulation, particularly in patients with renal impairment.
What this interaction means in plain words
Cephalexin and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of MATE1-mediated renal tubular secretion of metformin by cephalexin.
What to do
Monitor renal function and watch for signs of metformin toxicity; consider reducing the metformin dose in patients with impaired renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Cephalexin with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Cephalexin and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin may reduce renal tubular secretion of metformin and increase its plasma concentrations. This raises the risk of metformin accumulation, particularly in patients with renal impairment.
How serious is the interaction between Cephalexin and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for signs of metformin toxicity; consider reducing the metformin dose in patients with impaired renal function.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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