Drug interactions
Cephalexin + Glipizide-metformin
Severity: Moderate
Cephalexin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin can raise metformin concentrations, which may increase the risk of adverse effects including lactic acidosis in patients with other risk factors such as renal impairment.
What this interaction means in plain words
Cephalexin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cephalexin inhibits renal tubular transporters (OCT2/MATE) that eliminate metformin.
What to do
Monitor renal function and watch for gastrointestinal symptoms or lactic acidosis, especially in renal impairment; adjust metformin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Cephalexin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Cephalexin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin can raise metformin concentrations, which may increase the risk of adverse effects including lactic acidosis in patients with other risk factors such as renal impairment.
How serious is the interaction between Cephalexin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for gastrointestinal symptoms or lactic acidosis, especially in renal impairment; adjust metformin dose if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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