Drug interactions
Cephalexin + Meclofenamic acid
Severity: Minor
Cephalexin and Meclofenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin is eliminated by renal tubular secretion through anion transporters that NSAIDs also use. Meclofenamate may slightly reduce cephalexin clearance, and vice versa, with little clinical impact in most patients.
What this interaction means in plain words
Cephalexin and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
No dose adjustment is needed in normal renal function. In renal impairment, monitor renal function and for adverse effects of both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Cephalexin with Meclofenamic acid?
MediHelp rates the interaction as minor. Cephalexin and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalexin is eliminated by renal tubular secretion through anion transporters that NSAIDs also use. Meclofenamate may slightly reduce cephalexin clearance, and vice versa, with little clinical impact in most patients.
How serious is the interaction between Cephalexin and Meclofenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed in normal renal function. In renal impairment, monitor renal function and for adverse effects of both drugs.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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