Drug interactions
Cephalexin + Metformin-repaglinide
Severity: Moderate
Cephalexin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin may reduce renal tubular secretion of metformin and raise its plasma concentrations. This could increase the risk of metformin accumulation, particularly in patients with reduced kidney function.
What this interaction means in plain words
Cephalexin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cephalexin inhibits renal transporters (MATE1) involved in metformin elimination.
What to do
Monitor renal function and watch for metformin adverse effects, especially in patients with renal impairment; consider reducing the metformin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Cephalexin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Cephalexin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin may reduce renal tubular secretion of metformin and raise its plasma concentrations. This could increase the risk of metformin accumulation, particularly in patients with reduced kidney function.
How serious is the interaction between Cephalexin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for metformin adverse effects, especially in patients with renal impairment; consider reducing the metformin dose.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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