Drug interactions
Cephaloridine + Streptomycin
Severity: Major
Cephaloridine and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephaloridine is a cephalosporin with marked dose-related kidney toxicity, and combining it with an aminoglycoside increases the chance of kidney injury. Reduced renal function then causes streptomycin to accumulate, raising the risk of ototoxicity and vestibular toxicity.
What this interaction means in plain words
Cephaloridine and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with secondary accumulation of streptomycin as renal clearance falls.
What to do
Avoid the combination; cephaloridine is largely obsolete and an alternative beta-lactam should be chosen. If both are used, monitor renal function and streptomycin levels and adjust the dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Cephaloridine with Streptomycin?
MediHelp rates the interaction as major. Cephaloridine and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is a cephalosporin with marked dose-related kidney toxicity, and combining it with an aminoglycoside increases the chance of kidney injury. Reduced renal function then causes streptomycin to accumulate, raising the risk of ototoxicity and vestibular toxicity.
How serious is the interaction between Cephaloridine and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; cephaloridine is largely obsolete and an alternative beta-lactam should be chosen. If both are used, monitor renal function and streptomycin levels and adjust the dose.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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