Drug interactions
Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal
Severity: Contraindicated
Certolizumab pegol and Influenza virus vaccine quadrivalent intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine is a live attenuated product. In patients on certolizumab, the vaccine virus may replicate in an uncontrolled way and cause vaccine-related illness, while immune response may be reduced.
What this interaction means in plain words
Certolizumab pegol and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF blockade-related immunosuppression reduces control of replicating attenuated influenza virus.
What to do
Use the inactivated injectable influenza vaccine instead of the intranasal live vaccine in patients on certolizumab.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Certolizumab pegol and Influenza virus vaccine quadrivalent intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as contraindicated. Certolizumab pegol and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine is a live attenuated product. In patients on certolizumab, the vaccine virus may replicate in an uncontrolled way and cause vaccine-related illness, while immune response may be reduced.
How serious is the interaction between Certolizumab pegol and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated injectable influenza vaccine instead of the intranasal live vaccine in patients on certolizumab.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
