Drug interactions
Cevimeline + Isoniazid
Severity: Minor
Cevimeline and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP2D6 and CYP3A4, and isoniazid may weakly inhibit CYP3A4. A clinically meaningful increase is unlikely but cholinergic effects such as sweating and nausea could be more pronounced.
What this interaction means in plain words
Cevimeline and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid may slightly reduce cevimeline clearance.
What to do
No dose adjustment is needed. Monitor for excessive cholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Isoniazid?
MediHelp rates the interaction as minor. Cevimeline and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is metabolized by CYP2D6 and CYP3A4, and isoniazid may weakly inhibit CYP3A4. A clinically meaningful increase is unlikely but cholinergic effects such as sweating and nausea could be more pronounced.
How serious is the interaction between Cevimeline and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for excessive cholinergic effects.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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