Drug interactions
Chasteberry + Clozapine
Severity: Minor
Chasteberry and Clozapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chasteberry has dopaminergic activity and could theoretically reduce the antipsychotic effect of clozapine. No well-documented clinical cases exist.
What this interaction means in plain words
Chasteberry and Clozapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition between dopamine agonist activity of chasteberry and dopamine antagonism of clozapine.
What to do
Ask patients about herbal use and monitor for loss of psychiatric symptom control if chasteberry is used. Consider stopping the herb if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Chasteberry with Clozapine?
MediHelp rates the interaction as minor. Chasteberry and Clozapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chasteberry has dopaminergic activity and could theoretically reduce the antipsychotic effect of clozapine. No well-documented clinical cases exist.
How serious is the interaction between Chasteberry and Clozapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and monitor for loss of psychiatric symptom control if chasteberry is used. Consider stopping the herb if symptoms worsen.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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