Drug interactions
Chloral hydrate + Dexfenfluramine
Severity: Minor
Chloral hydrate and Dexfenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonergic anorectic, now withdrawn in most markets, with mixed effects on arousal. Its interaction with chloral hydrate is poorly characterized and sedation could be either increased or reduced.
What this interaction means in plain words
Chloral hydrate and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not established; possible opposing or variable CNS effects.
What to do
No specific action is needed beyond monitoring the sedative response and avoiding unnecessary dose escalation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloral hydrate and Dexfenfluramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Dexfenfluramine?
MediHelp rates the interaction as minor. Chloral hydrate and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexfenfluramine is a serotonergic anorectic, now withdrawn in most markets, with mixed effects on arousal. Its interaction with chloral hydrate is poorly characterized and sedation could be either increased or reduced.
How serious is the interaction between Chloral hydrate and Dexfenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring the sedative response and avoiding unnecessary dose escalation.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
