Drug interactions
Chloral hydrate + Epinephrine racemic
Severity: Moderate
Chloral hydrate and Epinephrine racemic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is a sympathomimetic, and chloral hydrate may sensitize the heart to catecholamines, potentially increasing the risk of arrhythmias. Any opposing effect on sedation is minor and unpredictable.
What this interaction means in plain words
Chloral hydrate and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical myocardial sensitization to catecholamines by chloral hydrate metabolites, with unpredictable opposing CNS effects.
What to do
Monitor heart rate and rhythm, particularly with systemic or repeated dosing of racemic epinephrine. Use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Epinephrine racemic?
MediHelp rates the interaction as moderate. Chloral hydrate and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine is a sympathomimetic, and chloral hydrate may sensitize the heart to catecholamines, potentially increasing the risk of arrhythmias. Any opposing effect on sedation is minor and unpredictable.
How serious is the interaction between Chloral hydrate and Epinephrine racemic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm, particularly with systemic or repeated dosing of racemic epinephrine. Use the lowest effective epinephrine dose.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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