Drug interactions
Chloral hydrate + Loprazolam
Severity: Moderate
Chloral hydrate and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loprazolam is a benzodiazepine hypnotic, and combining it with chloral hydrate produces additive sedation. This may cause excessive drowsiness, impaired coordination and respiratory depression, especially in older adults.
What this interaction means in plain words
Chloral hydrate and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A enhancement by both drugs.
What to do
Avoid concurrent hypnotics where possible; otherwise use lower doses and monitor sedation and breathing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Loprazolam?
MediHelp rates the interaction as moderate. Chloral hydrate and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loprazolam is a benzodiazepine hypnotic, and combining it with chloral hydrate produces additive sedation. This may cause excessive drowsiness, impaired coordination and respiratory depression, especially in older adults.
How serious is the interaction between Chloral hydrate and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent hypnotics where possible; otherwise use lower doses and monitor sedation and breathing.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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